Summary
The American Heart Association released a new online calculator, Predicting Risk of cardiovascular disease (CVD) EVENTs (PREVENTTM),1 that enhances cardiovascular disease risk estimates compared to the 2013 Pooled Cohort Equations (PCE). This risk calculator integrates more comprehensive health metrics, such as heart failure (HF), and provides a longer-term risk assessment across diverse populations.1
The PREVENT equations, validated in a diverse sample of more than 6 million individuals, provide estimates for individuals aged 30 to 79 years (vs. 45-79 years in the previous PCE model) and also provide estimates for both 10- and 30-year cardiovascular risk. The 30-year risk prediction, in particular, is posited to be useful for counseling younger adults in lower stages of cardiovascular-kidney-metabolic (CKM) syndrome.2
The new equations feature sex-specific risk calculators and removes race as a variable, recognizing it as a social construct rather than a biological factor. Additionally, new risk factors related to CKM conditions, such as body mass index (BMI), hemoglobin A1C, and urine albumin-creatinine ratio, along with an optional social deprivation index based on home zip code, have been integrated. Although the addition of these risk factors led to only modest improvements in risk prediction accuracy, the updated model now includes HF alongside traditional atherosclerotic CVD outcomes, with good risk discrimination observed across genders and racial groups.2,3
Sources
1. Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2023;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.
2. Razavi AC, Kohli P, McGuire DK, et al. PREVENT equations: a new era in cardiovascular disease risk assessment. Circ Cardiovasc Qual Outcomes. 2024;17(4). doi:10.1161/circoutcomes.123.010763.
3. Jackson, EA. New PREVENT equations for CVD risk assessment: key takeaways. American College of Cardiology. https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2024/04/01/14/20/prevent-equations-a-new. Published April 1, 2024. Accessed August 19, 2024.
This summary was created with assistance from generative artificial intelligence (ChatGPT, 2024)